Shabaana Khader
Prof Shabaana has broad background in Immunology, with specific training and expertise in the area of pulmonary inflammation and mucosal host defense, specifically in the field of mycobacterial infections. She has published several key findings in the area of immunity to tuberculosis in high impact journals such as Nature, Nature Immunology, Nature Microbiology, Science Translational Medicine, Immunity, Journal of Experimental Medicine, Journal of Clinical Investigation, Nature Communications, American Journal of Respiratory Medicine and Critical Care Medicine, and Mucosal Immunology, and these studies have been heavily cited in the literature. Her lab has been a pioneer in determining the parameters that mediate protective vaccine-induced immunity against TB. For example, her study describing a novel role for the cytokine Interleukin-17 in generating vaccine-induced immunity against tuberculosis that was published in Nature Immunology, has been cited over 1400 times. In the prior funding period of this R01, work from her lab has demonstrated that Th17 vaccine responses are critical for vaccine-induced immunity against TB, considerably changing the landscape of TB vaccine development. In addition, over the past 15 years her team have identified the immune factors necessary for Th17 mediated TB vaccine responses and delineated the protective-dependent mechanisms that contribute to Mtb control, and delineated drug resistance mutations that modulate host immune responses.
As evident from her publications and funding record, her lab has a long, strong and successful history of collaborating with leaders in the field of lung and vaccine biology, mucosal immunology and host immune responses. In addition, she is deeply committed to training and mentoring the next generation of scientists and faculty working in the research area of infectious diseases in general, and HIV/TB in particular.
Abstracts this author is presenting: