Nod-like receptors (NLR) represent an important family of cytosolic pattern-recognition receptors (PRRs) that contribute to innate and adaptive immune responses in mammals. In my presentation I will focus on NLR signalling of NOD1 and NLRC5.
The receptor interacting serine/threonine kinase 2 (RIPK2) is essential for linking activation of the pattern recognition receptors NOD1 and NOD2 to cellular signalling events. We recently demonstrated that RIPK2 forms detergent insoluble complexes in the cytosol of host cells upon infection with invasive enteropathogenic bacteria. I will summarize our current understanding of NOD1 activation and of RIPosome formation.
Others and we identified NLRC5 as the key transcriptional regulator of major histocompatibility (MHC) class I genes. Our recent observations suggest novel roles for NLRC5 also in metabolic traits. I will discuss our recent findings, revealing that Nlrc5 contributes to weight gain and adipose tissue development in mice which involves transcriptional enhancement of PPARĪ³ targets by NLRC5 that is co-regulated by Sin3A.