Dengue is an arboviral disease transmitted by Aedes aegypti mosquitoes, which causes a substantial health and economic burden for half of the world's population. Ae. aegypti also transmit chikungunya, Zika and yellow fever viruses, and its geographic range is expanding due to climate change, urbanisation and increased global connectivity. The World Mosquito Program (WMP) is a global not-for-profit initiative that aims to provide an innovative new tool for the prevention of Aedes-borne diseases using Wolbachia, a common insect bacteria. Stable infection of Ae. aegypti with wMel-strain Wolbachia significantly reduces their ability to transmit medically-important arboviruses including dengue, Zika and chikungunya, and manipulates the mosquitoes’ reproductive outcomes such that Wolbachia introgresses into wild Ae. aegypti populations following short-term open releases. I will present results from a cluster randomised trial in Indonesia and non-randomised field releases in 11 countries showing that releases of Wolbachia-infected mosquitoes have resulted in successful and sustained Wolbachia introgression into local Ae aegypti populations, and significant reductions in the incidence of dengue and other Aedes-borne diseases. The potential for large-scale Wolbachia implementation to lead to local elimination of dengue will be discussed.